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Azacitidine can be employed in vitro to eliminate methyl groups from DNA. This could weaken the consequences of gene silencing mechanisms that take place ahead of methylation.
Steer clear of staying in close proximity to people who are Unwell or have bacterial infections. Notify your medical professional simultaneously in case you establish indications of infection.
Renal toxicity starting from elevated serum creatinine to renal failure and Loss of life are actually described in sufferers handled with intravenous azacitidine in combination with other chemotherapeutic brokers for nonMDS ailments. Furthermore, renal tubular acidosis, defined as a slide in serum bicarbonate to < twenty mEq/L in Affiliation by having an alkaline urine and hypokalemia (serum potassium < 3 mEq/L) created in five individuals with CML treated with azacitidine and etoposide.
Get crisis medical support When you've got signs of an allergic reaction to Vidaza: hives; difficult respiration; swelling of your respective facial area, lips, tongue, or throat.
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Don't receive a "Stay" vaccine although acquiring Vidaza, and stay away from coming into contact with anybody who has lately been given a Reside vaccine.
Keep an eye on serum creatinine and electrolytes prior to initiation of therapy and with Every single cycle. If unexplained reductions in serum bicarbonate < 20 mEq/L or elevations of BUN or serum creatinine manifest, minimize or keep the dose [see DOSAGE AND ADMINISTRATION].
The concluded solution is equipped in a very sterile form for reconstitution being a suspension for subcutaneous injection or reconstitution as an answer with more dilution for intravenous infusion. Vials of VIDAZA consist of 100 mg of azacitidine and a hundred mg mannitol as being a sterile lyophilized powder.
Use start Manage to circumvent pregnancy while you're receiving Vidaza, regardless if you are a man or a lady. If a person fathers a child when utilizing Vidaza, the child could have delivery defects. Use a condom to forestall pregnancy during your remedy, and for a minimum of 4 months after your remedy finishes.
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